Several studies have shown toxic, mutagenic, carcinogenic, and teratogenic properties of patulin (Schumacher et al. 1977 Rice 1980 Roland and Beuchat 1984 Sant’Ana et al. nivea) showing high thermal resistance, they survive heat treatment during food processing and cause deterioration of fruit juices (Rice et al. 2015) and the generated patulin accumulates also in plums, strawberries, and kiwifruits (Neri et al. This fungus was also isolated from grapes (Tančinová et al. 2017) and other fruits like infected pears, peaches, or apricots (Neri et al. It is found in healthy as well as in rotten apple fruit (Hasan 2000 Hammami et al. In case of deterioration of fruits and their derived products, Penicillium and Byssochlamys are the most studied fungi with Penicillium expansum being the most common contaminant. Patulin is produced by several species of fungus belonging mainly to the genera of Aspergillus, Penicillium, and Byssochlamys however, others also synthesize this mycotoxin (Anderson et al. We focus on developments in sample preparation and the applied analytical conditions. This paper presents recently proposed LC methods with ultraviolet and mass spectrometric detection for patulin quantification in fruits and derived products. The preferred approach used for mycotoxin determination in a variety of foods is liquid chromatography (LC) allowing quantitative analysis of patulin content. Therefore, constant monitoring of different fruit-based products ought to be carried out to provide proper estimation of human exposure to this toxin. Patulin can also be generated during food storage and remains stable over food processing procedures. Most of them are seasonal, suitable for consumption for short time, and are usually processed in order to be commercially available throughout the year. However, the presence of patulin in other fruits, including stone fruits, and soft fruits has been reported as well. The main sources of patulin intake in human diet that was shown for EU consumers are apple juice and nectar and for this reason, apple-based food is most often monitored for this mycotoxin. Patulin is a mycotoxin that exhibits a number of toxic effects in animals.
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